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N7GCW > VETS 21.03.05 20:10l 31 Lines 1409 Bytes #999 (0) @ WW
BID : 40069_WA7V
Read: GUEST
Subj: Antibodies to SQUALENE
Path: DB0FHN<DB0RGB<OK0PPL<DB0RES<ON0AR<7M3TJZ<W7NTF<W1NGL<WA7V<WA7V
Sent: 050318/1636z @:WA7V.#SEWA.WA.USA.NOAM [Walla Walla] $:40069_WA7V
Antibodies to Squalene
Asa PB, Cao Y, Garry RF
Department of Microbiology, Tulane Medical School, 1430 Tulane Avenue,
New Orleans, Louisiana, 70112,
USA. PMBA@aol.com
Gulf War Syndrome (GWS) is a multisystemic illness afflicting many Gulf
War-era veterans. The molecular pathological basis for GWS has not been
established. We sought to determine whether the presence of antibodies
to squalene correlates with the presence of signs and symptoms of GWS.
Participants in this blinded cohort study were individuals immunized for
service in Desert Shield/Desert Storm during 1990-1991. They included 144
Gulf War-era veterans or military employees (58 in the blinded study),
48 blood donors, 40 systemic lupus erythematosus patients, 34 silicone
breast implant recipients, and 30 chronic fatigue syndrome patients. Serum
GWS patients had antibodies to squalene. All (100%) GWS patients immunized
for service in Desert Shield/Desert Storm who did not deploy, but had the
same signs and symptoms as those who did deploy, had antibodies to squalene.
In contrast, none (0%) of the deployed Persian Gulf veterans not showing
signs and symptoms of GWS have antibodies to squalene. Neither patients
with idiopathic autoimmune disease nor healthy controls had detectable
serum antibodies to squalene. The majority of symptomatic GWS patients
had serum antibodies to squalene.
Copyright 2000 Academic Press.
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